https://www.mancialab.com/home daily 1.0 2026-01-30 https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1555959970812-3N8PPJN3SLPOMSQR1CP4/image.jpg Home https://www.mancialab.com/publications daily 0.75 2026-01-30 https://www.mancialab.com/contact daily 0.75 2022-01-27 https://www.mancialab.com/research daily 0.75 2026-01-30 https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/2ed2db43-f880-44f4-83cc-80d45b56e248/41467_2025_66769_Fig1_HTML.webp Research - Make it stand out (a) Reaction catalyzed by GtrB. The Glc moiety (maroon) on UDP-Glc (teal) is transferred onto the UndP (purple) headgroup by GtrB, forming UndP-Glc. (b) Cartoon representation of ‘Flash-and-freeze’ system for cryo-TREM showing the travel of the cryo-EM grid before being vitrified on the left. (c) Cartoon of theoretical un-caging (pink) of UDP-Glc (teal) when bound to membrane-embedded GtrB after UV irradiation resulting in catalysis. (d) Cryo-EM density map of the substrate-bound state GtrB bound to UndP and UDP-Glc. On the right, the ribbon model of the substrate-bound state is shown with approximate membrane boundaries represented as dotted lines (e) Ribbon model of a GtrB protomer. https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1d299c02-0d20-4faa-84be-1a0fb701b62a/Screenshot+2026-01-30+150457.png Research - Make it stand out Cryo-EM density map of the PE- and KLA-bound MCR-1–Fab complex. Density corresponding to the Fab is shown in gray, and the PD and TM domain of MCR-1 are colored green and blue, respectively. The density for KLA is in red, and the density for PE in yellow. https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/daf09811-ad97-4796-810f-aec20e9c5fe5/wntwls.jpg Research - Make it stand out Structure of WNT8A in complex with WLS. The 3.2 Å structure of WNT8A bound to WLS with WLS colored in rainbow from N- (blue) to C- (red) terminus, and WNT8A in violet with a transparent surface. The PAM is represented as green spheres extending out between TM helices 4 and 5. Glycosylation of WNT8A at two sites is in red, as sticks. https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/848cd0aa-1ca9-42e0-8ec4-317921a4857e/Screenshot+2026-01-30+151838.png Research - Make it stand out Kim, J., Tan, Y.Z, Wicht, K.J.,3, Erramilli, S.K., Dhingra, S.K, Okombo. J., Vendome, J., Hagenah, L.M., Giacometti, S.I., Warren, A.L, Nosol, K., Roepe, P.D, Potter, C.S., Carragher, B., Kossiakoff, A.A., Quick, M., Fidock D.A. & Mancia, F. (2019) Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature (2019). https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/0cf7ceae-817f-4b3b-962e-8c874ef7d950/41586_2024_7326_Fig2_HTML.jpg Research - Make it stand out Cater, R.J., Mukherjee, D., Gil-Iturbe, E. et al. Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature (2024). https://www.mancialab.com/news daily 0.75 2024-06-07 https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/a126ca6a-56e8-45cc-b52d-b33694051404/movie2%282%29%281%29.GIF News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/3577cad2-3e09-4ffc-8ef5-191b4f7ae5a3/Ashraf_Figure1_v25_dimensions.jpg News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1623957463330-6B2QM43GO1O4YYKF0FZ2/mancia-cater_omega3_model.png News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1623956580757-JOBJNJ2XHZZCZENLIJG4/41586_2021_3650_Fig1_HTML.jpeg News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1614353726127-WVTX0XMCNXXLOM3HDOX6/Lipid-news-445x561.jpg News https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1610123222956-7WRHSAB3ORBUJ3IBSF5J/mancia_wntwntless.jpg News https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1610123286644-2VZGDTL7NX5VW9SB7MOV/graphical+abstract_v5.jpg News https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1588964133936-FZFJ0FV8IDTETCFHU0P6/molcel_78_4_4c-1.jpg News https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1575032560134-U6KUXWJYETJ6T05G85AE/p07wbzsp.jpg News https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1574881285353-CYRFI58FCA2Z7DJQ5484/Screen+Shot+2019-11-27+at+2.00.57+PM.png News https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1574880450548-O2QD9LGVDWXWANU8PCZT/Screen+Shot+2019-11-27+at+1.45.57+PM.png News https://www.mancialab.com/gallery daily 0.75 2024-06-07 https://www.mancialab.com/new-page-2 daily 0.75 2026-03-02 https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1555682406984-UFEJ9MJPP7W1T1PI2IIY/IMG_1352.jpg People https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/1585674649963-SHW2RNFG2JSK6DJLYKO8/JK.jpg People https://images.squarespace-cdn.com/content/v1/5cb60c65aadd3442fab29ef0/9eae07c4-81ef-4216-8fe0-114c471f88fa/aysenur.jpeg People - 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